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There is evidence linking an increase of the nephrotoxin indoxyl sulfate in the serum of uremic patients—which is caused by poor renal secretion—to gut microbiota dysbiosis toward a greater abundance of aerobic indole-producing bacteria (such as Escherichia coli ) (117, 118)

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In the lung, interstitial lung diseases (ILDs) represent a heterogeneous group of diseases driven by complex gene-environment interactions